Biologics are bacterial and viral vaccines, antigens, antitoxins and analogous products, serums, plasmas and other blood derivatives for therapeutically protecting or treating humans and animals. Bulks are active drug substances used to manufacture dosage- form products, process medicated animal feeds or compound prescription medications. Diagnostic agents assist the diagnosis of diseases and disorders in humans and animals. Diagnostic agents may be inorganic chemicals for examining the gastrointestinal tract, organic chemicals for visualizing the circulatory system and liver and radioactive compounds for measuring the function of organ system. Drugs are substances with active pharmacological properties in humans and animals.
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Biologics are bacterial and viral vaccines, antigens, antitoxins and analogous products, serums, plasmas and other blood derivatives for therapeutically protecting or treating humans and animals. Bulks are active drug substances used to manufacture dosage- form products, process medicated animal feeds or compound prescription medications. Diagnostic agents assist the diagnosis of diseases and disorders in humans and animals. Diagnostic agents may be inorganic chemicals for examining the gastrointestinal tract, organic chemicals for visualizing the circulatory system and liver and radioactive compounds for measuring the function of organ system.
Drugs are substances with active pharmacological properties in humans and animals. Drugs are compounded with other materials, such as pharmaceutical necessities, to produce a medicinal product. Ethical pharmaceuticals are biological and chemicals agents for preventing, diagnosing or treating disease and disorders in humans or animals.
These products are dispensed by prescription or approval of a medical, pharmacy or veterinary professional. Excipients are inert ingredients which are combined with drug substances to create a dosage form product.
Excipients may affect the rate of absorption, dissolution, metabolism and distribution in humans or animals. Over-the-counter pharmaceuticals are drug products sold in a retail store or pharmacy which do not require a prescription or the approval of a medical, pharmacy or veterinary professional.
Pharmacy is the art and science of preparing and dispensing drugs for preventing, diagnosing or treating diseases or disorders in humans and animals. Pharmacokinetics is the study of metabolic processes relating to the absorption, distribution, biotransformation, and elimination of a drug in humans or animals.
Pharmacodynamics is the study of drug action relating to its chemical structure, site of action, and the biochemical and physiological consequences in humans and animals. The pharmaceutical industry is an important component of health care systems throughout the world; it is comprised of many public and private organizations that discover, develop, manufacture and market medicines for human and animal health Gennaro Drug substances exhibit a wide range of pharmacological activity and toxicological properties Hardman, Gilman and Limbird ; Reynolds Modern scientific and technological advances are accelerating the discovery and development of innovative pharmaceuticals with improved therapeutic activity and reduced side effects.
Molecular biologists, medicinal chemists and pharmacists are improving the benefits of drugs through increased potency and specificity. These advances create new concerns for protecting the health and safety of workers within the pharmaceutical industry Agius ; Naumann et al. Many dynamic scientific, social and economic factors affect the pharmaceutical industry.
Some pharmaceutical companies operate in both national and multinational markets. Therefore, their activities are subject to legislation, regulation and policies relating to drug development and approval, manufacturing and quality control, marketing and sales Spilker Academic, government and industry scientists, practising physicians and pharmacists, as well as the public, influence the pharmaceutical industry.
Health care providers e. Government regulations and health care policies on pharmaceuticals are influenced by the public, advocacy groups and private interests. These complex factors interact to influence the discovery and development, manufacturing, marketing and sales of drugs. The pharmaceutical industry is largely driven by scientific discovery and development, in conjunction with toxicological and clinical experience see figure Major differences exist between large organizations which engage in a broad range of drug discovery and development, manufacturing and quality control, marketing and sales and smaller organizations which focus on a specific aspect.
Most multinational pharmaceutical companies are involved in all these activities; however, they may specialize in one aspect based upon local market factors. Academic, public and private organizations perform scientific research to discover and develop new drugs.
The biotechnology industry is becoming a major contributor to innovative pharmaceutical research Swarbick and Boylan Often, collaborative agreements between research organizations and large pharmaceutical companies are formed to explore the potential of new drug substances. Many countries have specific legal protections for proprietary drugs and manufacturing processes, known as intellectual property rights. In instances when legal protections are limited or do not exist, some companies specialize in manufacturing and marketing generic drugs Medical Economics Co.
Many countries have extensive government regulations affecting the development and approval of drugs for commercial sale. These countries have strict requirements for good manufacturing practices to ensure the integrity of drug manufacturing operations and the quality, safety and efficacy of pharmaceutical products Gennaro International and domestic trade, as well as tax and finance policies and practices, affect how the pharmaceutical industry operates within a country Swarbick and Boylan Significant differences exist between developed and developing countries, regarding their needs for pharmaceutical substances.
In developing countries, where malnutrition and infectious diseases are prevalent, nutritional supplements, vitamins and anti-infective drugs are most needed.
In developed countries, where the diseases associated with ageing and specific ailments are primary health concerns, cardiovascular, central nervous system, gastrointestinal, anti-infective, diabetes and chemotherapy drugs are in the greatest demand. Veterinarians administer drugs to control infectious diseases and parasitic organisms in agricultural and companion animals. Vaccines and anti-infective and antiparasitic drugs are commonly used for this purpose.
Nutritional supplements, antibiotics and hormones are widely employed by modern agriculture to promote the growth and health of farm animals. Many different biological and chemical agents are discovered, developed and used in the pharmaceutical industry Hardman, Gilman and Limbird ; Reynolds Some manufacturing processes in the pharmaceutical, biochemical and synthetic organic chemical industries are similar; however, the greater diversity, smaller scale and specific applications in the pharmaceutical industry are unique.
The pharmaceutical industry uses biological agents e. Biological agents are not addressed by this profile due to their unique pharmaceutical applications, but other references are readily available Swarbick and Boylan Chemical agents may be categorized as industrial chemicals and drug-related substances Gennaro These may be raw materials, intermediates or finished products.
Industrial chemicals are used in researching and developing active drug substances and manufacturing bulk substances and finished pharmaceutical products. Organic and inorganic chemicals are raw materials, serving as reactants, reagents, catalysts and solvents. The use of industrial chemicals is determined by the specific manufacturing process and operations. Many of these materials may be hazardous to workers. Since worker exposures to industrial chemicals may be hazardous, occupational exposure limits, such as threshold limit values TLVs have been established by government, technical and professional organizations ACGIH Pharmacologically active substances may be categorized as natural products and synthetic drugs.
Natural products are derived from plant and animal sources, while synthetic drugs are produced by microbiological and chemical technologies. Antibiotics, steroid and peptide hormones, vitamins, enzymes, prostaglandins and pheromones are important natural products.
Scientific research is focusing increasingly on synthetic drugs due to recent scientific advances in molecular biology, biochemistry, pharmacology and computer technology. Table Central nervous system Renal and cardiovascular system Gastrointestinal system Anti-infectives and target organs Immune system Chemotherapy Blood and blood-forming organs Endocrine system Analgesics.
Prostaglandins Active drug substances and inert materials are combined during pharmaceutical manufacturing to produce dosage forms of medicinal products e. Drugs may be categorized by their manufacturing process and therapeutic benefits EPA Drugs are medicinally administered by strictly prescribed means e.
Occupational exposure limits OELs are developed by toxicologists and occupational hygienists to provide guidance on limiting worker exposures to drug substances Naumann et al. Pharmaceutical necessities e. Many pharmaceutical necessities have no or limited therapeutic value and are relatively non-hazardous to workers during drug development and manufacturing operations. These materials are anti-oxidants and preservatives, colouring, flavouring and diluting agents, emulsifiers and suspending agents, ointment bases, pharmaceutical solvents and excipients.
Pharmaceutical manufacturing operations may be categorized as basic production of bulk drug substances and pharmaceutical manufacturing of dosage form products. Figure Basic production of bulk drug substances may employ three major types of processes: fermentation, organic chemical synthesis, and biological and natural extraction Theodore and McGuinn These manufacturing operations may be discrete batch, continuous or a combination of these processes.
Antibiotics, steroids and vitamins are produced by fermentation, whereas many new drug substances are produced by organic synthesis. Historically, most drug substances were derived from natural sources such as plants, animals, fungi and other organisms.
Natural medicines are pharmacologically diverse and difficult to produce commercially due to their complex chemistry and limited potency. Fermentation is a biochemical process employing selected micro-organisms and microbiological technologies to produce a chemical product. Batch fermentation processes involve three basic steps: inoculum and seed preparation, fermentation, and product recovery or isolation Theodore and McGuinn A schematic diagram of a fermentation process is given in figure Inoculum preparation begins with a spore sample from a microbial strain.
The strain is selectively cultured, purified and grown using a battery of microbiological techniques to produce the desired product. The spores of the microbial strain are activated with water and nutrients in warm conditions. Cells from the culture are grown through a series of agar plates, test tubes and flasks under controlled environmental conditions to create a dense suspension. The cells are transferred to a seed tank for further growth. The seed tank is a small fermentation vessel designed to optimize the growth of the inoculum.
The cells from the seed tank are charged to a steam sterilized production fermentor. Sterilized nutrients and purified water are added to the vessel to begin the fermentation. During aerobic fermentation, the contents of the fermentor are heated, agitated and aerated by a perforated pipe or sparger, maintaining an optimum air flow rate and temperature. After the biochemical reactions are complete, the fermentation broth is filtered to remove the micro-organisms, or mycelia.
The drug product, which may be present in the filtrate or within the mycelia, is recovered by various steps, such as solvent extraction, precipitation, ion exchange and absorption.
Solvents used for extracting the product table Precipitation is a method to separate the drug product from the aqueous broth. The drug product is filtered from the broth and extracted from the solid residues.
Copper and zinc are common precipitating agents in this process. Ion exchange or adsorption removes the product from the broth by chemical reaction with solid materials, such as resins or activated carbon.
The drug product is recovered from the solid phase by a solvent which may be recovered by evaporation. Source: EPA Worker safety hazards may be posed by moving machine parts and equipment; high pressure steam, hot water, heated surfaces and hot workplace environments; corrosive and irritating chemicals; heavy manual handling of materials and equipment; and high noise levels.
Worker exposures to solvent vapours may occur when recovering or isolating products. Worker exposures to solvents may result from uncontained filtration equipment and fugitive emissions for leaking pumps, valves and manifold stations during extraction and purification steps.
Since the isolation and growth of micro-organisms are essential for fermentation, biological hazards are reduced by employing non-pathogenic microbes, maintaining closed process equipment and treating spent broth before its discharge.
This segment of the primary metals industry encompasses companies that manufacture steel tubes, pipes, steel wire, and metal shapes from acquired iron or steel. Companies purchases iron or steel rods, bars or wire to produce wire. Very fine wires are used in many industries, such as tire wires, fences, and welding wires. Companies roll or draw shapes except wire. Examples of these shapes include plate, sheet, strip, rod, and bar. Hot-rolled and Cold-rolled strips Coils are a key input for automobiles.
List of Industries
Steel Product Manufacturing
A chemical plant is an industrial process plant that manufactures or otherwise processes chemicals , usually on a large scale. Other kinds of plants, such as polymer, pharmaceutical, food, and some beverage production facilities, power plants , oil refineries or other refineries , natural gas processing and biochemical plants, water and wastewater treatment, and pollution control equipment use many technologies that have similarities to chemical plant technology such as fluid systems and chemical reactor systems. Some would consider an oil refinery or a pharmaceutical or polymer manufacturer to be effectively a chemical plant. Petrochemical plants plants using chemicals from petroleum as a raw material or feedstock are usually located adjacent to an oil refinery to minimize transportation costs for the feedstocks produced by the refinery.
Amcor Flexibles L. Cheniere Energy Partners, L. Columbus Industries, Inc. CornellCookson, Inc. Diebold, Inc. Housmex, Inc. McFarland Cascade Holdings, Inc. Pacesetter Industries, Inc. ProAmpac Holdings, Inc.
Textile, Textile Product, and Apparel Manufacturing Industries
Additional Information. Show source. Show sources information Show publisher information. This statistic was assembled from several IVC chemical fiber industry updates.
These jobs are found in a factory, plant, or mill. They can also exist in a home, as long as products, not services, are created. For example, bakeries, candy stores, and custom tailors are considered manufacturing because they create products out of components. On the other hand, book publishing, logging, and mining are not considered manufacturing because they don't change the good into a new product. Construction is in its own category and is not considered manufacturing. This includes pay and benefits. They also reduced the number of jobs by replacing workers. Yet, 89 percent of manufacturers are leaving jobs unfilled.
Manufacturing India 2025
In cases where these groupings correspond with major groups, the major group heading is also in italics. The assembly of products from component parts is considered to be Manufacturing, except in cases where the activity is appropriately classified under Construction. The assembly and installation of machinery and equipment in mining, manufacturing, commercial and other business establishments is classified under the same group of Manufacturing as the manufacture of the item installed. Excluded is the assembly on site of prefabricated, integral parts of bridges, water tanks, storage and warehouse facilities, railway and elevated pedestrian bridges, and lift, escalator, plumbing, sprinkler, central heating, ventilating, air-conditioning, lighting and electrical wiring systems for buildings and mines and all kinds of structures which are construction activities if undertaken as a specialised activity. Establishments specialising in the installation of household appliances, such as stoves and ranges, refrigerators, washing machines and driers, are classified under the appropriate retail trade group.
Manufacturing is no longer simply about making physical products. Changes in consumer demand, the nature of products, the economics of production, and the economics of the supply chain have led to a fundamental shift in the way companies do business. Customers demand personalization and customization as the line between consumer and creator continues to blur. As technology continues to advance exponentially, barriers to entry, commercialization, and learning are eroding. New market entrants with access to new tools can operate at much smaller scale, enabling them to create offerings once the sole province of major incumbents. While large-scale production will always dominate some segments of the value chain, innovative manufacturing models—distributed small-scale local manufacturing, loosely coupled manufacturing ecosystems, and agile manufacturing—are arising to take advantage of these new opportunities. Meanwhile, the boundary separating product makers from product sellers is increasingly permeable. Manufacturers are feeling the pressure—and gaining the ability—to increase both speed to market and customer engagement.
Chemical fibers global production 2000-2018
While this may sound like science fiction, these kinds of factories have been a reality for more than 15 years. To imagine a world where robots do all the physical work, one simply needs to look at the most ambitious and technology-laden factories of today.
We manufacture and supply world class chemicals, fibers and plastics products that provide real competitive advantage for your business in your chosen marketplace. We believe it is possible to operate with zero incidents — zero personal injuries, zero process safety incidents and environmental releases. We work together as One Ascend to embrace this Commitment to Zero every day in every activity we do. Sustainability is about protecting people — our employees, their families, the communities in which we live and countless people across the globe.
Кроме того, тебе нет нужды беспокоиться - друзья не будут встревожены твоим отсутствием. Мы позаботимся об этом, хотя бы для собственной безопасности. В первый раз Серанис дала обещание, которого не смогла Алистра, сколько ни билась, не смогла вытянуть из Хедрона дальнейших объяснений.
Шут быстро пришел в себя от шока и панического бегства обратно к поверхности после того, как он остался один в подземельях Гробницы.
Обе стороны обменялись натянутыми приветствиями. Депутация расследователей поняла, что Олвину известна цель их похода, и неожиданная эта встреча, совершенно очевидно, несколько смутила сенаторов.